Pro-ceramides are biomimetic active ingredients associated, according to available scientific data, with supporting the endogenous production of ceramides by skin cells. Their approach differs from that of ceramides applied directly topically: rather than providing exogenous ceramides, pro-ceramides are linked in the literature to the upstream activation of metabolic pathways involved in their endogenous synthesis.
Ceramides are one of the major lipid components of the intercellular cement of the stratum corneum. They are associated, according to available data, with cellular cohesion and skin comfort. When their endogenous concentration decreases due to aging or external factors, the skin may appear drier and more sensitive.
Pro-ceramides are documented for their association with supporting enzymes involved in sphingolipid biosynthesis, notably serine palmitoyltransferase, the first enzyme in the synthesis pathway. This upstream action is linked, according to available data, to progressive support of skin comfort and preservation of hydration comfort over time.
The interest of pro-ceramides compared to classic ceramides is their documented action on the skin's natural mechanisms, for a sustained effect over time. The skin is associated with a progressively more supple, softer appearance and better protection against external factors.
Their profile is particularly documented for dry, sensitive, or stressed skin, which benefits from support of its natural lipid composition.
In summary, biomimetic active ingredients of interest for dry or stressed skin, associated with supporting endogenous sphingolipid production, skin comfort, and preservation of hydration comfort.
